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Novel curcumin analogue hybrids: Synthesis and anticancer activity.
- Source :
-
European Journal of Medicinal Chemistry . Aug2018, Vol. 156, p493-509. 17p. - Publication Year :
- 2018
-
Abstract
- In this study, twenty curcumin analogue hybrids as potential anticancer agents through regulation protein of TrxR were designed and synthesized. Results of anticancer activity showed that 5,7-dimethoxy-3-(3-(2-((1E, 4E)-3-oxo-5-(pyridin-2-yl)penta-1,4-dien-1- yl)phenoxy)propoxy)-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one (compound 7d) could induce gastric cancer cells apoptosis by arresting cell cycle, break mitochondria function and inhibit TrxR activity. Meanwhile, western blot revealed that this compound could dramatically up expression of Bax/Bcl-2 ratio and high expression of TrxR oxidation. These results preliminarily show that the important role of ROS mediated activation of ASK1/MAPK signaling pathways by this title compound. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CURCUMIN
*ANTINEOPLASTIC agents
*CANCER cells
*CURCUMINOIDS
*DRUGS
Subjects
Details
- Language :
- English
- ISSN :
- 02235234
- Volume :
- 156
- Database :
- Academic Search Index
- Journal :
- European Journal of Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 131295623
- Full Text :
- https://doi.org/10.1016/j.ejmech.2018.07.013