Oxadiazepine Synthesis by Formal [4+3] Cycloaddition of o‐Chloromethyl Arylsulfonamides with Nitrones Promoted by NaHCO3.

Abstract: An effective and facile method for the synthesis of highly substituted 1,2,3,5‐tetrahydrobenzo[e][1,2,4]‐oxadiazepines is described. A formal [4+3] cycloaddition of N‐(2‐(chloromethyl) phenyl) amides with nitrones afforded benzo[e][1,2,4]‐oxadiazepine derivatives with high atom economy and excellent yields (up to 97%). [ABSTRACT FROM AUTHOR]