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Polymer blend nanofibers containing polycaprolactone as biocompatible and biodegradable binding agent to fabricate electrospun three-dimensional scaffolds/structures.
- Source :
-
Polymer . Aug2018, Vol. 151, p299-306. 8p. - Publication Year :
- 2018
-
Abstract
- To develop tissue engineering scaffolds that possess similar morphological structures to natural extracellular matrices (ECMs) is a major technological challenge. Herein, the feasibility of utilizing polycaprolactone (PCL) as biocompatible and biodegradable binding agent to fabricate electrospun three-dimensional (3D) scaffolds has been demonstrated. The obtained 3D scaffolds are soft while elastic, and they possess interconnected and hierarchically structured pores with sizes in the range from sub-microns to hundreds of microns; hence, they are morphologically similar to natural ECMs thus well suited for cell functions and tissue formation. It is envisioned that various thermoplastic polymers could be fabricated into 3D nanofibrous scaffolds/structures by first making blend nanofibers with PCL followed by processing via the thermally induced (nanofiber) self-agglomeration (TISA) method and finally being thermally stabilized, and the resulting electrospun 3D nanofibrous scaffolds/structures might to be useful for a variety of applications (particularly those related to tissue engineering). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00323861
- Volume :
- 151
- Database :
- Academic Search Index
- Journal :
- Polymer
- Publication Type :
- Academic Journal
- Accession number :
- 131355745
- Full Text :
- https://doi.org/10.1016/j.polymer.2018.07.074