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Familial Clustering of Classic Kaposi Sarcoma.
- Source :
-
Journal of Infectious Diseases . 6/1/2004, Vol. 189 Issue 11, p2023-2026. 4p. - Publication Year :
- 2004
-
Abstract
- It is widely accepted that there is a causal association between Kaposi sarcoma­associated herpesvirus (KSHV) and Kaposi sarcoma (KS). However, the majority of individuals infected with KSHV never develop KS. Here, we present a unique familial case of classic KS, in which the disease occurs in 4 siblings who have no recognized underlying immunodeficiency. We examine risk factors that could play a role in this condition, including KSHV infection, KSHV DNA load, genetic variants of KSHV, infection with additional viruses, interleukin-6­promoter polymorphism, and HLA genotype. We hypothesize that a genetic susceptibility to KS, in combination with KSHV infection, may play an important role in the presented familial case. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 189
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 13135930
- Full Text :
- https://doi.org/10.1086/386308