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A versatile cathodic “signal-on” photoelectrochemical platform based on a dual-signal amplification strategy.
- Source :
-
Biosensors & Bioelectronics . Nov2018, Vol. 119, p63-69. 7p. - Publication Year :
- 2018
-
Abstract
- Novel cathodic photoelectrochemical (PEC) aptasensors for sensitive and selective determination of thrombin and Pb 2+ were developed based on a new dual-signal amplification strategy. The presence of gold nanoparticles (AuNPs) could quench the PEC signal of bismuth oxyiodide (BiOI). At the same time, the redox moiety G-quadruplex/hemin or ferrocene (Fc) was found to enhance the PEC signal of BiOI. So, in the presence of thrombin or Pb 2+ , the interaction between target and the aptamer resulted in the releasement of the AuNPs, as well as shorter distance between the redox moiety and the electrode surface. Hence dual-enhanced cathodic PEC biosensor strategy was realized. Under the optimized conditions, the detection limits of thrombin and Pb 2+ were 17.3 fM and 3.16 pM, respectively with good selectivity. At the same time, the PEC performance of redox moiety G-quadruplex/hemin and Fc was compared. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PHOTOELECTROCHEMISTRY
*THROMBIN
*PHOTOCURRENTS
*GOLD nanoparticles
*BISMUTH oxides
Subjects
Details
- Language :
- English
- ISSN :
- 09565663
- Volume :
- 119
- Database :
- Academic Search Index
- Journal :
- Biosensors & Bioelectronics
- Publication Type :
- Academic Journal
- Accession number :
- 131403475
- Full Text :
- https://doi.org/10.1016/j.bios.2018.07.068