A preliminary description of the command-and-control axis.

Objective: There is a body of evidence that supports the idea of a coordinated interplay between three large-scale cerebral networks, the default mode network (DMN), the control network (CTRL), and the salience network (SN). Interactions between these networks have been linked with the process of transitioning from internal to external mental states. Methods: Using meta-analytic software provided by BrainMap, we generated anatomic likelihood estimates (ALEs) of the DMN, SN, and CTRL networks. ALEs were displayed using Mango. Pre-constructed Region of Interests(ROIs) corresponding to the 180 cerebral parcellations published under the Human Connectome Project were used to identify the parcellations comprising each network. DSI-based fiber tracking was performed to establish the connectivity between parcellations of each network. Results: The DMN includes parcellations that localize to the posterior and anterior cingulate cortex and inferior parietal lobule. The CTRL network localizes to the dorsolateral prefrontal cortex and lateral parietal lobe. The SN localizes to the middle cingulate cortex and anterior insula. The SN also connects to SCEF, a parcellation in the supplementary motor area. Conclusion: The DMN is a well-known resting-state network that is anti-correlated with the CTRL network. The SN has been described as the switch between these two networks. The SN's connection to SCEF may explain how the brain prepares for proposed activity during such transfers. We propose models of three critical brain networks that play a role in the transition from internal to external mental states. Future studies will refine these models of the command-and-control axis for clinical application. [ABSTRACT FROM AUTHOR]