Back to Search
Start Over
CD8+CD28+ T cells might mediate injury of cardiomyocytes in acute myocardial infarction.
- Source :
-
Molecular Immunology . Sep2018, Vol. 101, p74-79. 6p. - Publication Year :
- 2018
-
Abstract
- Highlights • Few paper investigates the role of CD8+CD28+ T cells in patients with AMI. • The frequency of CD8+CD28+ T cells in patients with AMI were significant increased. • In patients with AMI, frequency of CD8+CD28+ T cells was positively correlated with TNI and negatively associated with LVEF. • The CD8+ CD28+ T cell might participate in the process of myocardial damage. Abstract CD8+ T cells accumulate in the necrotic myocardium of acute myocardial infarction (AMI). It is unclear whether CD8+CD28+ T cells, a specific subset of CD8+ T cells, contribute to myocardial injury. In this study, 92 consecutive patients with AMI and 28 healthy control subjects were enrolled. The frequency of CD8+CD28+ T cells in peripheral blood samples was assayed by flow cytometry. Plasma cardiac troponin I (TNI) and left ventricular ejection fraction (LVEF) were determined. Long-term prognosis of the patients was evaluated by major adverse cardiac and cerebrovascular events (MACCE) over a 12-month follow-up period. Our findings indicated that patients with AMI who presented with high numbers of CD8+CD28+ T cells had an increased infarction size and aggravated ventricular function. We proposed that cytotoxic CD8+CD28+ T cell-mediated myocardial necrosis may act as a novel and alternative pathway of AMI. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MYOCARDIAL infarction
*HEART cells
*CD8 antigen
*CD28 antigen
*T cells
Subjects
Details
- Language :
- English
- ISSN :
- 01615890
- Volume :
- 101
- Database :
- Academic Search Index
- Journal :
- Molecular Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 131730760
- Full Text :
- https://doi.org/10.1016/j.molimm.2018.05.015