Manganese(III) Acetylacetonate‐Mediated Phosphorylation of Enamides at Room Temperature.

Abstract: A highly Z‐selective phosphorylation by Manganese(III) acetylacetonate‐mediated cross‐dehydrogenative‐coupling of enamides and phosphine oxides has been developed under mild conditions. The reaction shows broad substrate scope and functional group compatibility. DFT studies revealed that the formation of Z‐products is presumably due to the presence of an intramolecular hydrogen bond. β‐Aminophosphine could be readily obtained by reduction and hydrolysis of the product. [ABSTRACT FROM AUTHOR]