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Multidrug Toxicity Involving Sumatriptan.
- Source :
-
Journal of Analytical Toxicology . Jan2015, Vol. 39 Issue 1, p75-79. 5p. 1 Diagram, 4 Charts. - Publication Year :
- 2015
-
Abstract
- A multidrug fatality involving sumatriptan is reported. Sumatriptan is a tryptamine derivative that acts at 5-HT1B/1D receptors and is used for the treatment of migraines. The decedent was a 21-year-old white female found dead in bed by her spouse. No signs of physical trauma were observed and a large number of prescription medications were discovered at the scene. Toxicological analysis of the central blood revealed sumatriptan at a concentration of 1.03 mg/L. Following therapeutic dosing guidelines, sumatriptan concentrations do not exceed 0.095 mg/L. Sumatriptan was isolated by solid-phase extraction and analyzed using liquid chromatography–tandem mass spectrometry in multiple reaction monitoring mode. A tissue distribution study was completed with the following concentrations measured: 0.61 mg/L in femoral blood, 0.56 mg/L in iliac blood, 5.01 mg/L in urine, 0.51 mg/kg in liver, 3.66 mg/kg in kidney, 0.09 mg/kg in heart, 0.32 mg/kg in spleen, 0.01 mg/kg in brain, 15.99 mg/kg in lung and 78.54 mg/45 mL in the stomach contents. Carisoprodol, meprobamate, fluoxetine, doxylamine, orphenadrine, dextromethorphan and hydroxyzine were also present in the blood at the following concentrations: 3.35, 2.36, 0.63, 0.19, 0.06, 0.55 and 0.16 mg/L. The medical examiner ruled the cause of death as acute mixed drug toxicity and the manner of death as accident. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01464760
- Volume :
- 39
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Analytical Toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 131905149
- Full Text :
- https://doi.org/10.1093/jat/bku120