Quantitative path to deep phenotyping: Possible importance of reduced hepatic insulin degradation to type 2 diabetes mellitus pathogenesis.

The article discusses the use of deep phenotyping in diabetes and the association between reduced hepatic insulin degradation and type 2 diabetes mellitus (T2DM) pathogenesis. Several factors that determine glucose tolerance are discussed including hepatic insulin clearance, variation in hepatic insulin extraction, and insulin signaling. Particular focus is also given to insulin resistance and &#946-cell function.