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Synthesis of new thioxanthenes by organocatalytic intramolecular Friedel-Crafts reaction.
- Source :
-
Synthetic Communications . 2018, Vol. 48 Issue 17, p2177-2188. 12p. 3 Diagrams, 4 Charts. - Publication Year :
- 2018
-
Abstract
- An efficient organocatalytic route has been developed to synthesize novel substituted thioxanthenes (2a-2v) starting from diaryl thioether alcohols (1a-1v) using the intramolecular Friedel-Crafts reaction. The starting materials were obtained in two stages via a coupling reaction followed by the Grignard reaction. In this study, we tried for the first time to use some organic Brønsted acids as organocatalysts (3a-3h) in the intramolecular Friedel-Crafts cyclization reaction of thioether alcohols. The synthesis of original substituted thioxanthenes was achieved within 15 minutes by using N-triflylphosphoramide (3h) with quantitative yields in THF at room temperature. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00397911
- Volume :
- 48
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- Synthetic Communications
- Publication Type :
- Academic Journal
- Accession number :
- 132089713
- Full Text :
- https://doi.org/10.1080/00397911.2018.1482351