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A new C,N-cyclometalated osmium(II) arene anticancer scaffold with a handle for functionalization and antioxidative properties.
- Source :
-
Chemical Communications . 10/11/2018, Vol. 54 Issue 79, p11120-11123. 4p. - Publication Year :
- 2018
-
Abstract
- A series of sixosmium(II) complexes of the type [(η6-p-cymene)Os(C^N)X] (X = chlorido or acetato) containing benzimidazole C^N ligands with an ester group as a handle for further functionalization have been synthesized. They exhibit IC50 values in the lowmicromolar range in a panel of cisplatin (CDDP)-resistant cancer cells (approximately 10x more cytotoxic than CDDP in MCF-7), decrease the levels of intracellular ROS and reduce the NAD+ coenzyme, and inhibit tubulin polymerization. This discovery could open the door to a new large family of osmium(II)-based bioconjugates with diverse modes of action. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 54
- Issue :
- 79
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 132100304
- Full Text :
- https://doi.org/10.1039/c8cc06427j