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Long-term Outcome of Resective Epilepsy Surgery in Patients With Lennox-Gastaut Syndrome.
- Source :
-
Pediatrics . Oct2018, Vol. 142 Issue 4, p1-9. 9p. - Publication Year :
- 2018
-
Abstract
- OBJECTIVE: We aimed to evaluate the long-term outcome of resective epilepsy surgery in patients with Lennox-Gastaut syndrome (LGS). METHODS: We reviewed the case reports of 90 patients with LGS who had undergone resective surgery between 2003 and 2014 at the Severance Children's Hospital and managed them for a minimum period of 2 years. RESULTS: At the time of surgery, the patients were between 3.0 and 23.5 years old (mean ± SD: 9.3 ± 4.4). The time from seizure onset to surgery ranged from 0.7 to 20.1 years (7.2 ± 4.3). On postoperative follow-up for an average period of 6.1 ± 2.2 years (range: 2.1--11.4 years), 45 patients (50.0%) had no seizures, and 15 (16.7%) reported infrequent seizures. Seizure-free outcomes were achieved in 15 of the 21 (71.4%) hemispherectomies, 23 of the 51 (45.1%) multilobar resections, and 7 of the 18 (38.9%) single lobar resections. On high-resolution MRIs, 20 patients (22.2%) had negative findings, 8 of whom (40.0%) became seizure-free after resective surgery. Malformation of cortical development was the most common pathologic finding and was noted in 57 patients (63.3%). Seizure-free patients achieved better adaptive behavior and social competence than did patients with persistent seizures at the second (2--3 years after surgery) and third (4--6 years after surgery) follow-ups, as indicated by social quotients (P < .05). CONCLUSIONS: Resective surgery is a viable option in some patients to treat seizures that are associated with LGS, with a high probability of seizure control and better adaptive function. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SPASMS
*SEIZURES (Medicine)
*CEREBRAL cortex abnormalities
*PHYSIOLOGICAL adaptation
*NEURAL development
*CHILDREN'S hospitals
*LENNOX-Gastaut syndrome
*MAGNETIC resonance imaging
*NEUROSURGERY
*POSTOPERATIVE period
*SOCIAL skills
*TREATMENT effectiveness
*TREATMENT duration
*DIAGNOSIS
*PREVENTION
CEREBRAL cortex surgery
Subjects
Details
- Language :
- English
- ISSN :
- 00314005
- Volume :
- 142
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 132171278
- Full Text :
- https://doi.org/10.1542/peds.2018-0449