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Correlation-based perfusion mapping using time-resolved MR angiography: A feasibility study for patients with suspicions of steno-occlusive craniocervical arteries.
- Source :
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European Radiology . Nov2018, Vol. 28 Issue 11, p4890-4899. 10p. 3 Color Photographs, 3 Charts, 2 Graphs. - Publication Year :
- 2018
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Abstract
- <bold>Purpose: </bold>To explore the feasibility of using correlation-based time-delay (CTD) maps produced from time-resolved MR angiography (TRMRA) to diagnose perfusion abnormalities in patients suspected to have steno-occlusive lesions in the craniocervical arteries.<bold>Materials and Methods: </bold>Twenty-seven patients who were suspected to have steno-occlusive lesions in the craniocervical arteries underwent both TRMRA and brain single-photon emission computed tomography (SPECT). TRMRA was performed on the supra-aortic area after intravenous injection of a 0.03 mmol/kg gadolinium-based contrast agent. Time-to-peak (TTP) maps and CTD maps of the brain were automatically generated from TRMRA data, and their quality was assessed. Detection of perfusion abnormalities was compared between CTD maps and the time-series maximal intensity projection (MIP) images from TRMRA and TTP maps. Correlation coefficients between quantitative changes in SPECT and parametric maps for the abnormal perfusion areas were calculated.<bold>Results: </bold>The CTD maps were of significantly superior quality than TTP maps (p < 0.01). For perfusion abnormality detection, CTD maps (kappa 0.84, 95% confidence interval [CI] 0.67-1.00) showed better agreement with SPECT than TTP maps (0.66, 0.46-0.85). For perfusion deficit detection, CTD maps showed higher accuracy (85.2%, 95% CI 66.3-95.8) than MIP images (66.7%, 46-83.5), with marginal significance (p = 0.07). In abnormal perfusion areas, correlation coefficients between SPECT and CTD (r = 0.74, 95% CI 0.34-0.91) were higher than those between SPECT and TTP (r = 0.66, 0.20-0.88).<bold>Conclusion: </bold>CTD maps generated from TRMRA were of high quality and offered good diagnostic performance for detecting perfusion abnormalities associated with steno-occlusive arterial lesions in the craniocervical area.<bold>Key Points: </bold>• Generation of perfusion parametric maps from time-resolved MR angiography is clinically useful. • Correlation-based delay maps can be used to detect perfusion abnormalities associated with steno-occlusive craniocervical arteries. • Estimation of correlation-based delay is robust for low signal-to-noise 4D MR data. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MAGNETIC resonance angiography
*STENOSIS
*PERFUSION
*COMPUTER-assisted image analysis (Medicine)
*CEREBROVASCULAR disease diagnosis
*ARTERIAL occlusions
*CEREBRAL arteries
*INTRAVENOUS injections
*RESEARCH funding
*PILOT projects
*SINGLE-photon emission computed tomography
*CONTRAST media
*DRUG administration
*DRUG dosage
*DIAGNOSIS
ARTERIAL abnormalities
Subjects
Details
- Language :
- English
- ISSN :
- 09387994
- Volume :
- 28
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- European Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 132188051
- Full Text :
- https://doi.org/10.1007/s00330-018-5468-1