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Fe(ClO4)3·H2O-Catalyzed Ritter Reaction: A Convenient Synthesis of Amides from Esters and Nitriles.
- Source :
-
Synlett . 2017, Vol. 29 Issue 17, p2257-2264. 8p. - Publication Year :
- 2018
-
Abstract
- An efficient and inexpensive synthesis of N-substituted amides from the Ritter reaction of nitriles with esters catalyzed by Fe(ClO4)3·H2O is described. Fe(ClO4)3·H2O is an economically efficient catalyst for the Ritter reaction under solvent-free conditions. Reactions of a range of esters (benzyl, sec-alkyl, and tert-butyl esters) with nitriles (primary, secondary, tertiary, and aryl nitriles) were performed to provide the corresponding amides in high to excellent yields. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AMIDE synthesis
*NITRILE synthesis
*CATALYSIS
Subjects
Details
- Language :
- English
- ISSN :
- 09365214
- Volume :
- 29
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- Synlett
- Publication Type :
- Academic Journal
- Accession number :
- 132260107
- Full Text :
- https://doi.org/10.1055/s-0037-1610658