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Factors affecting the live-birth rate in women with diminished ovarian reserve undergoing IVF-ET.
- Source :
-
Archives of Gynecology & Obstetrics . Nov2018, Vol. 298 Issue 5, p1017-1027. 11p. 1 Diagram, 2 Charts, 4 Graphs. - Publication Year :
- 2018
-
Abstract
- <bold>Purpose: </bold>The occurrence of diminished ovarian reserve (DOR) in women was growing in recent years. Although in vitro fertilization and embryo transfer (IVF-ET) became an effective treatment for DOR, the live-birth (LB) rate remains unsatisfactory. This study aimed to investigate the impact factors of LB rate in women with DOR undergoing assisted reproduction.<bold>Methods: </bold>This was a single-center retrospective cohort study. A total of 2277 IVF-ET or ICSI cycles from 1957 DOR women were analysed. Impact factors of LB rate were explored via Student's t test, Pearson's Chi-square test, and multivariate logistic regression models.<bold>Results: </bold>There were statistically significant differences in maternal age (P < 0.001), duration of infertility (P < 0.001), female body mass index (P = 0.039), first IVF cycle (P = 0.004), poor ovarian response (P < 0.001), paternal age (P < 0.001), total gonadotropin dose (P = 0.010), endometrial thickness (P = 0.021), number of follicles ≥ 14 mm (P = 0.007), number of oocytes retrieved (P < 0.001), number of frozen embryos (P = 0.014), and the stage (P < 0.001) and number (P < 0.001) of embryos transferred between the non-live-birth (NLB) and LB groups. However, only factors of maternal age, the stage and number of embryos transferred remained different after adjusting for potential confounders.<bold>Conclusions: </bold>Maternal age, the stage and number of embryos transferred were independent impact factors affecting the live-birth rate in women with DOR seeking for assisted conception. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OVARIAN reserve
*FERTILIZATION (Biology)
*HUMAN artificial insemination
*BODY mass index
*HUMAN fertility
*INFERTILITY treatment
*RESEARCH
*BIRTH rate
*RESEARCH methodology
*SPERM motility
*RETROSPECTIVE studies
*EVALUATION research
*MEDICAL cooperation
*PREGNANCY outcomes
*EMBRYO transfer
*COMPARATIVE studies
*MATERNAL age
*OVARIAN diseases
*RESEARCH funding
*FERTILIZATION in vitro
*INDUCED ovulation
*LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 09320067
- Volume :
- 298
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Archives of Gynecology & Obstetrics
- Publication Type :
- Academic Journal
- Accession number :
- 132294519
- Full Text :
- https://doi.org/10.1007/s00404-018-4884-4