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Peripheral tumor necrosis factor-a-induced protein 8-like 2 mRNA level for predicting 3-month mortality of patients with acute ischemic stroke.
- Source :
-
Journal of Neurology . Nov2018, Vol. 265 Issue 11, p2573-2586. 14p. 1 Diagram, 4 Charts, 3 Graphs. - Publication Year :
- 2018
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Abstract
- Tumor necrosis factor-a-induced protein 8-like 2 (TIPE2) is a novel negative regulator for maintaining immune homeostasis. This study aimed to investigate TIPE2 mRNA in peripheral blood mononuclear cells for predicting 3-month functional outcomes and mortality of patients with acute ischemic stroke. A total of 182 consecutive patients were prospective collected, and there were 55 (30.2%) patients with unfavorable outcome and 33 (18.1%) patients died at the end of 3 months. The area under the operating characteristic curve (AUC) for TIPE2 mRNA was 0.810 (95% CI 0.733-0.886) for mortality and 0.740 (95% CI 0.662-0.818) for unfavorable outcome. The model incorporating National Institutes of Health Stroke Scale (NIHSS) plus TIPE2 showed significantly (P = 0.04) increased discrimination power (AUC = 0.925, 95% CI 0.874-0.976) for mortality than NIHSS (AUC = 0.882, 95% CI 0.833-0.932). Furthermore, NIHSS plus TIPE2 showed a significant improvement of both integrated discrimination index (IDI) and net reclassification index (NRI) as compared with NIHSS (IDI = 0.224, 95% CI 0.150-0.299, P < 0.001; NRI = 1.119, 95% CI 0.810-1.429, P < 0.001). The pruned time-dependent tree analysis showed that patients with NIHSS ≥ 5.5 and TIPE2 mRNA < 5.2 had rather high 3-month mortality. In conclusion, TIPE2 mRNA improved the diagnostic value of NIHSS score, and patients with NIHSS ≥ 5.5 and TIPE2 mRNA < 5.2 had high 3-month mortality. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TUMOR necrosis factors
*HOMEOSTASIS
*STROKE
*MESSENGER RNA
*MORTALITY
Subjects
Details
- Language :
- English
- ISSN :
- 03405354
- Volume :
- 265
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Journal of Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 132348779
- Full Text :
- https://doi.org/10.1007/s00415-018-9036-z