全麻药物对神经发育影响的争鸣.

General anesthetics are widely used in millions of neonates and infants for operations and medical examination every year. The safety of anesthetic has also become a growing concern. Although animal studies show the anesthetic neurotoxicity, it is con­fusing that the current clinical researches are not consistent. More studies are needed to investigate the anesthetic neurotoxicity and mini­mize the side effect of anesthetic. This article describes the advantages and limitations of animal and clinical researches on anesthetic neurotoxicity in recent years, shows the time-dependence and dose-dependence of anesthetic neurotoxicity Evidence in recent studies suggesting that single, relatively brief exposures to surgical procedures requiring general anesthesia are not associated with detectable deficits in neurodevelopment. It is essential that more studies are needed to investigate the association between anesthesia and neurode­velopment, especially the multiple expose, and to guide the practice. [ABSTRACT FROM AUTHOR]