百令胶囊联合信必可对中重度稳定期慢性阻塞性肺疾病患者 肺功能及免疫功能的影响

Objective: To investigate the effect of bailing capsule combined with symbicort on lung function and immunologic function of moderate to severe cliromc obstructive pulmonary disease (COPD) patients, in order to provide the basis for clinical use of the drug. Methods: A total of 104 COPD patients, who were treated in Baoji Traditional Cliinese Medicine Hospital of Shaanxi Province froin August 2015 to January 2017. were selected and randomly divided into single drug group(n=52) and combination group{n=52). The single drug group was given single symbicort and routine health education, on the basis of which, the combination group was given bailing capsule. Forced vital capacity (FVC), forced expiratory volume in the first second (FEV1) and the ratio of them (FEV1 FVC) of all the patients before treatment and after 12 weeks of treatment were detected, and the CD3~ CD4T cells and CD4"'CD8" ratio were measured. The efficacy of patients in the two groups were observed and compared. Results: After 12 weeks of treatment, FVC, FEV1 and FEV1/FVC of the two groups were significantly increased, and compared with single drug group, the FVC. FEV1 andFEVlFVC of the combination group were significantly higher (all P<O.05). After 12 weeks of treatment. CD3+, CD4+T and CD4+ CD8+ of the two groups were significantly increased, and compared with single drug group, the CD3+, CD4+ and CD4+/CD8+ of die combination group were significantly higher (all P<-0.05). The total effective rate(86.54%) of the combination group was significantly higher than that(67.31%) of the single drug group (P<0.05). Conclusion: Baihng capsule combined with symbicort has a significant effect on moderate to severe COPD patients. It can effectively improve the patients' lung function and immune function, which is worth popularizing in clinic. [ABSTRACT FROM AUTHOR]