西安市2010-2015 年0-5 岁儿童HBV感染状况的流行病学研究.

Objective: To master the trend and epidemiological characteristics of hepatitis B infection in children aged 0-5 years2010-2015 years in Xi'an and find the high risk population of hepatitis B infection in children. To analyze the disease prognosis and the problem of hepatitis B monitoring system through follow-up and provide a scientific basis for the improvement of hepatitis B monitoring system and the development of prevention and control strategies. Methods: Descriptive epidemiological method was used to describe the distribution of hepatitis B patients with hepatitis B among children aged 0-5 years in Xi'an area during the period of 2010-2015. By using the method of cohort study and detection the HBV virus in peripheral blood of mothers and children, then the prognosis of children with hepatitis B was obtained. Results: A total of 175 cases of hepatitis B were reported in children aged 0-5 years in Xi'an during the period of 2010-2015, with an average annual HBV infection rate of 6.05/10 million, which was highest in 2013, for 9.73/10 million, mainly distributed. Boys were more than girls. 0-1 years old was the high incidence of age. Yanta District and Weiyang District were the highest incidence area. By the end of August 2016, 139 preschool children were followed up for HBV infection. Only 17 patients completed the epidemiological investigation and physical examination, the dropout rate was as high as 87.7%, Up to 88.2%. 17 cases of children were chronic HBV infection, including 14 cases(82.3%) were HBs Ag positive mothers. Conclusion: The high risk population of HBV infection among children aged 0-5 in Xi'an area were children whose mothers were HBs Ag positive, which may be related to the vertical and Horizontal transmission of HBV of mother and child. 0-5 years old HBV-infected children had poor outcome. To strengthen the work of HBV intrauterine blocking and monitor the hepatitis B antibody in high-risk neonates was recommended. [ABSTRACT FROM AUTHOR]