P20.05: Efficiency and limits of the non‐invasive prenatal genetic testing: a comparative review.

The development of the genetic non-invasive prenatal tests (NIPT) has been an issue during the last years all over the world, in order to reduce the number of invasive investigations for fetal aneuploidies. From the 120 papers identified, 23 presented data on the prenatal detection rate of the fetal aneuploidies using several non-invasive prenatal tests and matched our inclusion criteria. The use of the non-invasive prenatal tests promises an encouraging accuracy and precision, the sensitivity and specificity in prenatal detection of the fetal aneuploidies being superior to the known screening tests such as the double test with a detection rate of 90-95% and with 3-5% of false positive results. [Extracted from the article]