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The morphological and functional significance of the NOS/NO system in the respiratory, osmoregulatory, and contractile organs of the African lungfish.
- Source :
-
Acta Histochemica . Oct2018, Vol. 120 Issue 7, p654-666. 13p. - Publication Year :
- 2018
-
Abstract
- Abstract This review aims to summarize the changes of the NOS/NO system which occur in the lungs, gills, kidney, heart, and myotomal muscle of air breathing fish of the genus Protopterus , i.e. P. dolloi and P. annectens , in relation to the switch from freshwater to aestivation, and vice-versa. The modifications of NOS and its partners Akt and Hsp-90, and HIF-1α, detected by immunohistochemical and molecular biology methods, are discussed together with the apoptosis rate, evaluated by TUNEL. We hypothesize that these molecular components are key elements of the stress-induced signal transduction/integration networks which allow the lungfish to overcome the dramatic environmental challenges experienced at the beginning, during, and at the end of the dry season. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00651281
- Volume :
- 120
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Acta Histochemica
- Publication Type :
- Academic Journal
- Accession number :
- 132488737
- Full Text :
- https://doi.org/10.1016/j.acthis.2018.08.011