儿茶酚胺抑素对急性心梗大鼠室性心律失常的影响.

Objective To explore the correlation between the catestatin (CST) level and ventricular arrhythmia (VA) in acute myocardial infarction (AMI). Methods Sixty male rats were randomly divided into sham group (n=20) and AMI group (n=40). Myocardial infarction was produced by ligation of the left anterior descending coronary artery. Thirty-six rats in AMI groupsurvived. Both groups were detected for plasma CST level, ventricular arrhythmia susceptibility, ventricular vulnerable period and effective refractory period so as to evaluate the effect of CST on VA in AMI. Results Compared with that in sham group, LVEF reduced significantly in AMI group (P <0.01), while LVEDD, LVESD and CST increased (P <0.01). After programmed electrical stimulation, in AMI group VA was induced in 31 rats (86.1%) (P<0.01), ventricular vulnerable period extended, and effective refractory period shortened (P<0.01). Logistic regression analysis showed that decreased LVEF and increased CST were the independent risk factors of VA in AMI rats (P<0.01 to P<0.05). Conclusion The CST level is an independent risk factor for VA in AMI; therefore, it can be used to evaluate the prognosis of AMI. [ABSTRACT FROM AUTHOR]