T Follicular Regulatory Cells Are Decreased in Patients With Established Treated Rheumatoid Arthritis With Active Disease: Comment on the Article by Liu et al.

The authors present a study focusing on T follicular regulatory cells (Tfr) in patients with rheumatoid arthritis (RA). Topics discussed include the phenotype and human circulating Tfr cells (2); the treatment of the patients with methotrexate; and the anti–citrullinated protein antibody levels in the body.