Kidney damage induced by sub-chronic fine particulate matter exposure.

Abstract According to the WHO, about 3 million people die each year due to ambient air pollution. Most of the in vivo studies on the PM 2.5 effects have been done on respiratory and cardiovascular tissues. However, little is known about the effects on the tissues involved on xenobiotic removal, such as kidneys. In the present study we assess the harmful effects of sub-chronic exposure to PM 2.5 on the kidney, by investigating histologic and serum alterations in healthy and hypertensive rat models. Mean PM 2.5 concentrations during exposures were slightly above the daily WHO standard. Exposed animals showed fibrosis, mesangial expansion, decrease glomerular and tubular lumen volumes in kidneys, with an elevated BUN. Hypertensive animals also exhibited much more severe alterations than healthy animals. We conclude that PM 2.5 induces minimal or small-scale abnormalities that can be determinant for renal health preservation. Highlights • Exposure to PM 2.5 may induce fibrosis and mesangial expansion. • Exposure may also induce BUN elevation. • Particles' concentrations were below the WHO reference levels most days. • Hypertensive animals display much more severe alterations than healthy animals. [ABSTRACT FROM AUTHOR]