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Effects of dietary coated‐oleum cinnamomi supplementation on the immunity and intestinal integrity of broiler chickens.
- Source :
-
Animal Science Journal . Nov2018, Vol. 89 Issue 11, p1581-1590. 10p. - Publication Year :
- 2018
-
Abstract
- Oleum cinnamomi (OCM) is increasingly used as a feed additive in animal diets. The aim of this study was to investigate the effects of dietary supplementation with coated‐OCM (cOCM) on the immunity and intestinal integrity of broiler chickens. A total of 396 one‐day‐old chicks were randomly assigned into six groups. The basal diets were supplemented with 50 mg/kg of flavomycin (positive control) as well as 0 (control), 50, 100, 200, and 300 mg/kg of cOCM. Compared with the control, both positive control and cOCM treatments did not improve the growth performance. Serum immunoglobulin (Ig) Y levels were decreased by flavomycin and 50 mg/kg of cOCM treatments (p < 0.05). Dietary cOCM decreased ileal secretory IgA contents at d 21 and commonly down‐regulated duodenal and ileal mRNA expression of interleukin (IL)‐1β and IL‐8 at d 42 (p < 0.05). The 300 mg/kg of cOCM increased jejunal ratio of villus height to crypt depth and upregulated intestinal claudin‐1 expression (p < 0.05). Jejunal (at d 21) and duodenal (at d 42) mucin‐2 expression was up and downregulated by both 50 and 300 mg/kg of cOCM, respectively (p < 0.05). In conclusion, dietary cOCM addition helped to maintain noninflammatory states of humoral and mucosal immunity, and improved the intestinal integrity of broiler chickens. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13443941
- Volume :
- 89
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Animal Science Journal
- Publication Type :
- Academic Journal
- Accession number :
- 132809843
- Full Text :
- https://doi.org/10.1111/asj.13094