Electrospinning: An enabling nanotechnology platform for drug delivery and regenerative medicine.

Abstract Electrospinning provides an enabling nanotechnology platform for generating a rich variety of novel structured materials in many biomedical applications including drug delivery, biosensing, tissue engineering, and regenerative medicine. In this review article, we begin with a thorough discussion on the method of producing 1D, 2D, and 3D electrospun nanofiber materials. In particular, we emphasize on how the 3D printing technology can contribute to the improvement of traditional electrospinning technology for the fabrication of 3D electrospun nanofiber materials as drug delivery devices/implants, scaffolds or living tissue constructs. We then highlight several notable examples of electrospun nanofiber materials in specific biomedical applications including cancer therapy, guiding cellular responses, engineering in vitro 3D tissue models, and tissue regeneration. Finally, we finish with conclusions and future perspectives of electrospun nanofiber materials for drug delivery and regenerative medicine. Graphical abstract This review summarizes the methods for producing 1D electrospun fragment, 1D nanofiber bundles, 2D nanofiber membranes, and 3D nanofiber scaffolds. Next, the combination of electrospinning with 3D printing, flexible electrode, and microfluidcs are discussed. And the review highlights the biomedical applications of nanofiber scaffolds, including drug delivery, controlling cellular behaviors, engineering in vitro 3D tissue/tumor models, and regenerative medicine. Unlabelled Image [ABSTRACT FROM AUTHOR]