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Biomimetic fabrication of new bioceramics-introduced fibrous scaffolds: From physicochemical characteristics to in vitro biological properties.
- Source :
-
Materials Science & Engineering: C . Jan2019, Vol. 94, p547-557. 11p. - Publication Year :
- 2019
-
Abstract
- Abstract The combination of biodegradable polymers and bioactive inorganic materials is a promising method to mimic native tissue in bone regeneration. Toward this direction, electrospun fibrous scaffolds were successfully fabricated in the silk fibroin (SF) matrix containing new bioceramics on the basis of mesoporous bioactive glass/hydroxyapatite nanocomposite (MGHA). The physicochemical properties and surface hydrophilicity of these biphasic composite could be tailored by the addition of MGHA content. The increase in surface hydrophilicity and bioactivity of the as-spun composite fibers were observed with the increasing the nanoparticle contents while decreasing their tensile strength. In vitro cytotoxicity evaluation based on human bone marrow-derived mesenchymal stem cells (hMSCs) revealed that a positive osteogenic differentiation effect on SF/MGHA7 sample as evidenced by an increased alkaline phosphatase (ALP) activity, and upregulated osteoblastic gene expression compared with SF samples. These findings supported the suitability of the SF/MGHA composite system for its potential application in cell–material combination in bone tissue engineering. Graphical abstract Unlabelled Image Highlights • An organic-inorganic electrospun fibrous scaffold was fabricated by the combination of SF and MGHA. • The MGHA addition increased the surface hydrophilicity and bioactivity whereas decreasing the tensile strength. • The obtained membrane promoted hMSCs adhesion and proliferation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09284931
- Volume :
- 94
- Database :
- Academic Search Index
- Journal :
- Materials Science & Engineering: C
- Publication Type :
- Academic Journal
- Accession number :
- 132868977
- Full Text :
- https://doi.org/10.1016/j.msec.2018.09.063