Ventral striatum links motivational and motor networks during operant-conditioned movement in rats.

Abstract Voluntary actions require motives. It is already known that the medial prefrontal cortex (MPFC) assess the motivational values. However, it remains unclear how the motivational process gains access to the motor execution system in the brain. Here we present evidence that the ventral striatum (VS) plays a hub-like role in mediating motivational and motor processing in operant behavior. We used positron emission tomography (PET) to detect the neural activation areas associated with motivational action. Using obtained regions, partial correlation analysis was performed to examine how the motivational signals propagate to the motor system. The results revealed that VS activity propagated to both MPFC and primary motor cortex through the thalamus. Moreover, muscimol injection into the VS suppressed the motivational behavior, supporting the idea of representations of motivational signals in VS that trigger motivational behavior. These results suggest that the VS-thalamic pathway plays a pivotal role for both motivational processing through interactions with the MPFC and for motor processing through interactions with the motor BG circuits. Highlights • We established a procedure for measuring cerebral metabolic changes in rats at the whole brain during forelimb movement. • Striatal activities propagate to the medial prefrontal cortex and motor systems in parallel through the thalamus during operant action. • Reward-related and motor-related circuits have interacted each other through the ventral striatum-thalamic pathway. [ABSTRACT FROM AUTHOR]