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Highly Enantiospecific Borylation for Chiral α‐Amino Tertiary Boronic Esters.
- Source :
-
Angewandte Chemie . 11/12/2018, Vol. 130 Issue 46, p15358-15362. 5p. - Publication Year :
- 2018
-
Abstract
- Herein we report a highly efficient and enantiospecific borylation method to synthesize a wide range of enantiopure (>99 % ee) α‐amino tertiary boronic esters. The configurationally stable α‐N‐Boc substituted tertiary organolithium species and pinacolborane (HBpin) underwent enantiospecific borylation at −78 °C with the formation of a new stereogenic C−B bond. This reaction has a broad scope, enabling the synthesis of various α‐amino tertiary boronic esters in excellent yields and, importantly, with universally excellent enantiospecificity (>99 % es) and complete retention of configuration. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00448249
- Volume :
- 130
- Issue :
- 46
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie
- Publication Type :
- Academic Journal
- Accession number :
- 132874043
- Full Text :
- https://doi.org/10.1002/ange.201809389