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The Diverse Family of MR1-Restricted T Cells.
- Source :
-
Journal of Immunology . 11/15/2018, Vol. 201 Issue 10, p2862-2871. 10p. - Publication Year :
- 2018
-
Abstract
- Mucosal-associated invariant T (MAIT) cells are characterized by a semi-invariant TCR that recognizes vitamin B metabolite Ags presented by the MHC-related molecule MR1. Their Ag restriction determines a unique developmental lineage, imbuing a tissue-homing, preprimed phenotype with antimicrobial function. A growing body of literature indicates that MR1-restricted T cells are more diverse than the MAIT term implies. Namely, it is increasingly clear that TCR a- and TCR b-chain diversity within the MR1-restricted repertoire provides a potential mechanism of Ag discrimination, and context-dependent functional variation suggests a role for MR1-restricted T cells in diverse physiological settings. In this paper, we summarize MR1-restricted T cell biology, with an emphasis on TCR diversity, Ag discrimination, and functional heterogeneity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *T cells
*LYMPHOCYTES
*CD4 antigen
*ANTIBIOTICS
*HETEROGENEITY
Subjects
Details
- Language :
- English
- ISSN :
- 00221767
- Volume :
- 201
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Journal of Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 132884622
- Full Text :
- https://doi.org/10.4049/jimmunol.1801091