Intramolecular cyclization reactions of aziridines with π-nucleophiles

Authors :: Bergmeier, Stephen C.
Katz, Steven J.
Huang, Junfeng
McPherson, Howard
Donoghue, Patrick J.
Reed, Damon D.
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Jun2004, Vol. 45 Issue 26, p5011-5014. 4p.
Publication Year :: 2004
Abstract: We have found that aziridines will react with a variety of π-nucleophiles in intramolecular cyclization reactions to produce nitrogen containing core structures found in a variety of bioactive molecules. These cyclizations are more general and facile than corresponding intermolecular reactions. We have examined the effects of ring size, π-nucleophile identity and substitution on this reaction. [Copyright &y& Elsevier]

Subjects :: *NITROGEN
*MOLECULES
*RING formation (Chemistry)
*BIOACTIVE compounds

Language :: English
ISSN :: 00404039
Volume :: 45
Issue :: 26
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 13289805
Full Text :: https://doi.org/10.1016/j.tetlet.2004.05.009