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Toxic effects of natural piperine and its derivatives on epimastigotes and amastigotes of Trypanosoma cruzi
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Jul2004, Vol. 14 Issue 13, p3555-3558. 4p. - Publication Year :
- 2004
-
Abstract
- We describe herein an evaluation of trypanocidal effects of the natural alkaloid piperine and twelve synthetic derivatives against epimastigote and amastigote forms of the protozoan parasite Trypanosoma cruzi, the causative agent of the incurable human disease, Chagas'' disease. The results obtained point to piperine as a suitable template for the development of new drugs with trypanocidal activity. [Copyright &y& Elsevier]
- Subjects :
- *POISONS
*ALKALOIDS
*TRYPANOSOMA cruzi
*AMASTIGOTES
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 14
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 13290117
- Full Text :
- https://doi.org/10.1016/j.bmcl.2004.04.019