Highly enantioselective Michael/cyclization tandem reaction between dimedone and isatylidene malononitriles.

Abstract A highly enantioselective Michael/cyclization tandem reaction between dimedone and isatylidene malononitriles has been developed. With 5 mol% of bifunctional organocatalyst C15 , chiral spiro[2-amino-4 H -pyran-oxindole] derivatives were obtained in excellent yields (97–99%) with excellent enantioselectivities (up to > 99% ee). Graphical abstract Image 1 [ABSTRACT FROM AUTHOR]