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miRNAs in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis.
- Source :
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Journal of Hepatology . Dec2018, Vol. 69 Issue 6, p1335-1348. 14p. - Publication Year :
- 2018
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Abstract
- Graphical abstract Highlights • miRNA-34a, miRNA-122 and miRNA-192 helped to distinguish NAFLD and NASH severity. • The correlation of miRNA expression between serum and liver tissue was inconsistent. • miRNA-122 showed moderate accuracy to distinguish NAFLD from healthy controls. • miRNA-34a showed moderate accuracy to distinguish NASH from NAFL. Background & Aims microRNAs (miRNAs) are deregulated in non-alcoholic fatty liver disease (NAFLD) and have been proposed as useful markers for the diagnosis and stratification of disease severity. We conducted a meta-analysis to identify the potential usefulness of miRNA biomarkers in the diagnosis and stratification of NAFLD severity. Methods After a systematic review, circulating miRNA expression consistency and mean fold-changes were analysed using a vote-counting strategy. The sensitivity, specificity, positive and negative likelihood ratios, diagnostic odds ratio and area under the curve (AUC) for the diagnosis of NAFLD or non-alcoholic steatohepatitis (NASH) were pooled using a bivariate meta-analysis. Deeks' funnel plot was used to assess the publication bias. Results Thirty-seven studies of miRNA expression profiles and six studies of diagnostic accuracy were ultimately included in the quantitative analysis. miRNA-122 and miRNA-192 showed consistent upregulation. miRNA-122 was upregulated in every scenario used to distinguish NAFLD severity. The miRNA expression correlation between the serum and liver tissue was inconsistent across studies. miRNA-122 distinguished NAFLD from healthy controls with an AUC of 0.82 (95% CI 0.75–0.89), and miRNA-34a distinguished non-alcoholic steatohepatitis (NASH) from non-alcoholic fatty liver (NAFL) with an AUC of 0.78 (95% CI 0.67–0.88). Conclusion miRNA-34a, miRNA-122 and miRNA-192 were identified as potential diagnostic markers to segregate NAFL from NASH. Both miRNA-122, in distinguishing NAFLD from healthy controls, and miRNA-34a, in distinguishing NASH from NAFL, showed moderate diagnostic accuracy. miRNA-122 was upregulated in every scenario of NAFL, NASH and fibrosis. Lay summary microRNAs are deregulated in non-alcoholic fatty liver disease. The microRNAs, miRNA-34a, miRNA-122 and miRNA-192, were identified as potential biomarkers of non-alcoholic fatty liver and non-alcoholic steatohepatitis, at different stages of disease severity. The correlation between miRNA expression in the serum and in liver tissue was inconsistent, or even inverse. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MICRORNA
*FATTY liver
*META-analysis
*GENE expression
*DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 01688278
- Volume :
- 69
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 133045469
- Full Text :
- https://doi.org/10.1016/j.jhep.2018.08.008