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Directing T cell fate: How thymic antigen presenting cells coordinate thymocyte selection.
- Source :
-
Seminars in Cell & Developmental Biology . Dec2018, Vol. 84, p2-10. 9p. - Publication Year :
- 2018
-
Abstract
- Graphical abstract Abstract The development of a self-tolerant and effective T cell receptor repertoire is dependent on interactions coordinated by various antigen presenting cells (APC) within the thymus. T cell receptor–self-peptide–MHC interactions are essential for determining T cell fate, however different cytokine and co-stimulatory signals provided by the diverse APCs within the thymus are also critical. Here, we outline the different localization and functional capabilities of thymic APCs. We also discuss how these distinct APCs work collectively to facilitate the establishment of a diverse T cell receptor repertoire that is tolerant to an array of different self-antigens. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANTIGEN presenting cells
*THYMOCYTES
*T cell receptors
*DENDRITIC cells
*CYTOKINES
Subjects
Details
- Language :
- English
- ISSN :
- 10849521
- Volume :
- 84
- Database :
- Academic Search Index
- Journal :
- Seminars in Cell & Developmental Biology
- Publication Type :
- Academic Journal
- Accession number :
- 133046853
- Full Text :
- https://doi.org/10.1016/j.semcdb.2017.07.045