PPARα 与 2 型糖尿病性骨质疏松的相关性研究进展.

In China，the incidence of diabetes mellitus (DM) is increasing each year，with a trend of incident age getting younger， especially type 2 diabetes mellitus (T2DM) which is related to metabolic disorders and obesity． Diabetic osteoporosis (DOP) has been the concern of scholars，but its pathogenesis is still unclear． Anti-osteoporosis treatment is the main treatment method ，while early monitoring，early detection and early intervention cannot be achieved for the time being． Studies have found that PPAR alpha has differential expression in the bone marrow of diabetic rats，the expression level of PPAR alpha and DOP are inextricably linked， and the mechanism may be related to oxidative stress，insulin resistance (IR) or PI3K /Akt and NF-kB signaling pathways． This article aimed to review the progress of research on PPAR alpha and bone metabolism in T2DM patients． [ABSTRACT FROM AUTHOR]