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Absolute configuration determination of angular dihydrocoumarins from Peucedanum praeruptorum.
- Source :
-
Journal of Asian Natural Products Research . Sep2004, Vol. 6 Issue 3, p177-184. 8p. 2 Diagrams, 1 Chart, 3 Graphs. - Publication Year :
- 2004
-
Abstract
- From Peucedanum praeruptorum, one new khellactone ester (3′ R )- O -acetyl-(4′ S )- O -angeloylkhellactone ( 3 ), as well as four known angular dihydropyranocoumarins ( 1 , 2 , 4 , 5 ) have been isolated. On the basis of NMR spectra and X-ray crystallography, their structures were determined. We have elucidated their absolute configuration by either chiral separation of their alkaline hydrolysis products with Rp-18 HPLC eluted with 5% hydroxypropyl-β-cyclodextrin (β-HCD) or by measurement of their CD spectra. A general rule relating the position and absolute stereochemistry of the khellactone esters to the sign of their Cotton effects in CD curves is proposed. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ESTERS
*UMBELLIFERAE
*X-ray crystallography
*HYDROLYSIS
*STEREOCHEMISTRY
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 6
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 13309267
- Full Text :
- https://doi.org/10.1080/10286020310001653255