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Genomic Characterization of β-Glucuronidase-Positive Escherichia coli O157:H7 Producing Stx2a.
- Source :
-
Emerging Infectious Diseases . Dec2018, Vol. 24 Issue 12, p2219-2227. 9p. - Publication Year :
- 2018
-
Abstract
- Among Shiga toxin (Stx)-producing Escherichia coli (STEC) O157:H7 strains, those producing Stx2a cause more severe diseases. Atypical STEC O157:H7 strains showing a β-glucuronidase-positive phenotype (GP STEC O157:H7) have rarely been isolated from humans, mostly from persons with asymptomatic or mild infections; Stx2a-producing strains have not been reported. We isolated, from a patient with bloody diarrhea, a GP STEC O157:H7 strain (PV15-279) that produces Stx2a in addition to Stx1a and Stx2c. Genomic comparison with other STEC O157 strains revealed that PV15-279 recently emerged from the stx1a/stx2c-positive GP STEC O157:H7 clone circulating in Japan. Major virulence genes are shared between typical (β-glucuronidase-negative) and GP STEC O157:H7 strains, and the Stx2-producing ability of PV15-279 is comparable to that of typical STEC O157:H7 strains; therefore, PV15-279 presents a virulence potential similar to that of typical STEC O157:H7. This study reveals the importance of GP O157:H7 as a source of highly pathogenic STEC clones. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ESCHERICHIA coli
*VEROCYTOTOXINS
*ESCHERICHIA coli toxins
*PATHOGENIC microorganisms
*ENTEROBACTERIACEAE
*METABOLISM
*BACTERIAL toxins
*COMPARATIVE studies
*DNA
*ESCHERICHIA coli diseases
*BIOLOGICAL evolution
*GENETIC polymorphisms
*GENOMES
*GLYCOSIDASES
*RESEARCH methodology
*MEDICAL cooperation
*RESEARCH
*MICROBIAL virulence
*BIOINFORMATICS
*GENOMICS
*EVALUATION research
*MITOMYCINS
Subjects
Details
- Language :
- English
- ISSN :
- 10806040
- Volume :
- 24
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Emerging Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 133142148
- Full Text :
- https://doi.org/10.3201/eid2412.180404