Confronting the Challenges of Severe Asthma.

The article discusses the essential factors to be considered before the development of asthma treatment plan which include ensuring proper diagnosis of severe asthma, considering phenotypes and endotypes, and understanding advantages and disadvantages of available therapies. The clinical trial evidence for add-on asthma treatment options including pharmacologic therapies, omalizumab and reslizumab is explored. The associated biomarkers of asthma are also tackled.