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Nail involvement in patients with moderate-to-severe alopecia areata treated with oral tofacitinib.
- Source :
-
Journal of Dermatological Treatment . Dec2018, Vol. 29 Issue 8, p819-822. 4p. - Publication Year :
- 2018
-
Abstract
- Background: A few anecdotal case reports demonstrated that tofacitinib improved nail changes associated with AA. Objective: To investigate nail changes in patients with AA treated with tofacitinib and evaluate the relationship between nail and hair responses to tofacitinib. Methods: This is a retrospective study of 33 adult patients with moderate-to-severe AA treated with oral tofacitinib monotherapy for at least 4 months. Results: Fifteen patients had nail involvement and demonstrated more severe hair loss than those without nail involvement (pā=ā.040). However, there was no significant difference in hair regrowth between two groups. Of 15 patients with nail involvement, 11 (73.3%) showed improvement regardless of type of nail change; the first improvement was observed at a median of 5 months (range, 1-11) after administration. Nail improvement was associated with neither initial severity of hair loss nor hair response to tofacitinib. Nail improvement tended to occur later than hair regrowth. Conclusions: Oral tofacitinib monotherapy improves nail involvement associated with AA. Nail involvement is not a poor prognosis factor in hair regrowth with tofacitinib treatment and there is no evident relationship between nail and hair responses. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09546634
- Volume :
- 29
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Journal of Dermatological Treatment
- Publication Type :
- Academic Journal
- Accession number :
- 133159578
- Full Text :
- https://doi.org/10.1080/09546634.2018.1466024