α‐Amino Acid Sulfonamides as Versatile Sulfonylation Reagents: Silver‐Catalyzed Synthesis of Coumarins and Oxindoles by Radical Cyclization.

We developed a silver‐catalyzed strategy for the generation of sulfonyl radicals from sulfonamides derived from α‐amino acids. The reaction proceeded via a decarboxylation, N–S bond cleavage and radical cyclization sequence and allows the difunctionalization of alkynes and the synthesis of 3‐sulfonylated coumarins. The reaction tolerated a broad scope of substrates and functional groups and could be extended to the synthesis of oxindoles and an isoquinolinedione by the capturing of the sulfonyl radical with an alkene moiety. Moreover, the proposed mechanism was supported experimentally and by DFT calculations. A silver‐catalyzed sulfonylation strategy using sulfonamides derived from α‐amino acids is described. The reaction proceeded via decarboxylation, N–S bond cleavage and radical cyclization to provide a variety of coumarins. The reaction was suitable for the synthesis of 2‐oxindoles and an isoquinolinedione by the capturing of the sulfonyl radical with an alkene moiety and cyclization. [ABSTRACT FROM AUTHOR]