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Emerging potential benefits of modulating NAD+ metabolism in cardiovascular disease.
- Source :
-
American Journal of Physiology: Heart & Circulatory Physiology . Apr2018, Vol. 314 Issue 4, pH839-H852. 14p. - Publication Year :
- 2018
-
Abstract
- Nicotinamide adenine dinucleotide (and+) NAD related metabolites are central mediators of fuel oxidation and bioenergetics within cardiomyocytes. Additionally, NAD+ is required for the activity of multifunctional enzymes, including sirtuins and poly(ADP-ribose) polymerases that regulate posttranslational modifications, DNA damage responses, and Ca2+ signaling. Recent research has indicated that NAD+ participates in a multitude of processes dysregulated in cardiovascular diseases. Therefore, supplementation of NAD+ precursors, including nicotinamide riboside that boosts or repletes the NAD+ metabolome, may be cardioprotective. This review examines the molecular physiology and preclinical data with respect to NAD+ precursors in heart failure-related cardiac remodeling, ischemic-reperfusion injury, and arrhythmias. In addition, alternative NAD+-boosting strategies and potential systemic effects of NAD+ supplementation with implications on cardiovascular health and disease are surveyed. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CARDIOVASCULAR diseases
*MITOCHONDRIA
Subjects
Details
- Language :
- English
- ISSN :
- 03636135
- Volume :
- 314
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- American Journal of Physiology: Heart & Circulatory Physiology
- Publication Type :
- Academic Journal
- Accession number :
- 133179223
- Full Text :
- https://doi.org/10.1152/ajpheart.00409.2017