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Structures of the hydrate and dihydrate forms of the DNA-binding radioprotector methylproamine.
- Source :
-
Acta Crystallographica Section E: Crystallographic Communications . 2018, Vol. 74 Issue 12, p1903-1907. 19p. - Publication Year :
- 2018
-
Abstract
- Methyl proamine {N,N,3-trimethyl-4-[6-(4-methylpiperazin-1-yl)-1H,3'H-[2,5'-bibenzo[d]imidazol]-2'-yl]aniline}, C28H35N7O2, crystallized as both a dihydrate, C28H31N7·2H2O, and monohydrate, C28H31N7·H2O, form from water in the presence of β-cyclodextrin, in the P21/c and P21/n space groups, respectively. The two structures adopt different conformations and tautomeric forms as a result of the differing crystal packing as dictated by hydrogen-bonding interactions. The dihydrate crystallizes as a three-dimensional hydrogen-bonded network, while the monohydrate crystallizes as a two-dimensional hydrogenbonded network. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HYDRATES
*HYDROGEN bonding interactions
*CRYSTAL structure
Subjects
Details
- Language :
- English
- ISSN :
- 20569890
- Volume :
- 74
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Acta Crystallographica Section E: Crystallographic Communications
- Publication Type :
- Academic Journal
- Accession number :
- 133468111
- Full Text :
- https://doi.org/10.1107/S2056989018016791