IDENTIFICATION OF EFFECTIVE DOSES IN BINARY MIXTURES.

This paper proposes a model for estimation of the dose-response relationship of a two-component mixture. It puts forth a method for determination of combinations of active binary agents. A modified logistic function is used as analytic model for determining the dose-effect. Isobolographic curve is approximated by an exponential function. The identification procedure is based on the cyclic coordinate descent method. The approach is implemented in the computer program KORELIA-Dynamics. [ABSTRACT FROM AUTHOR]