Back to Search
Start Over
Nickel‐Catalyzed Mizoroki–Heck‐Type Reactions of Unactivated Alkyl Bromides.
- Source :
-
Angewandte Chemie . Dec2018, Vol. 130 Issue 51, p17099-17102. 4p. - Publication Year :
- 2018
-
Abstract
- The development of a general, nickel‐catalyzed alkyl‐Mizoroki–Heck reaction of unactivated alkyl bromides is described. The mild reaction proceeds efficiently using a wide range of primary and secondary alkyl bromides, and examples of intermolecular cross‐couplings are provided. Reaction alkene regioselectivity is significantly enhanced over prior carbocyclizations using palladium catalysis. Mechanistic investigations are consistent with a direct carbocyclization in contrast to the auto‐tandem atom‐transfer cyclization and halide elimination previously observed with palladium catalysis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NICKEL
*HECK reaction
*ALKYL bromides
*RING formation (Chemistry)
*PALLADIUM
Subjects
Details
- Language :
- English
- ISSN :
- 00448249
- Volume :
- 130
- Issue :
- 51
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie
- Publication Type :
- Academic Journal
- Accession number :
- 133500276
- Full Text :
- https://doi.org/10.1002/ange.201810757