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Facile synthesis of unnatural β-germyl-α-amino amides via Pd(ii)-catalyzed primary and secondary C(sp3)–H bond germylation.
- Source :
-
Chemical Communications . 12/28/2018, Vol. 54 Issue 100, p14136-14139. 4p. - Publication Year :
- 2018
-
Abstract
- Pd(ii)-Catalyzed direct C(sp3)–H germylation of α-AA derivatives with the assistance of a bidentate auxiliary for the efficient synthesis of β-germyl-α-amino amides is reported. This protocol features good generality for primary and secondary C–H bonds of aliphatic amides. Mechanistic studies show that a crucial five-membered palladacycle intermediate may play a key role in this process. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AMIDES
*CHEMICAL reactions
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 54
- Issue :
- 100
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 133545644
- Full Text :
- https://doi.org/10.1039/c8cc08098d