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NaBArF4‐Catalyzed Oxidative Cyclization of 1,5‐ and 1,6‐Diynes: Efficient and Divergent Synthesis of Functionalized γ‐ and δ‐Lactams.
- Source :
-
Chinese Journal of Chemistry . Jan2019, Vol. 37 Issue 1, p58-62. 5p. - Publication Year :
- 2019
-
Abstract
- Summary of main observation and conclusion: An efficient NaBArF4‐catalyzed oxidative cyclization of readily available 1,5‐ and 1,6‐diynes has been developed. Importantly, this transition metal‐free oxidative catalysis proceeds via a presumable Lewis acid‐catalyzed SN2' pathway, which is distinct from the relevant oxidative rhodium and gold catalysis. This method leads to the facile and practical construction of a diverse range of synthetically useful γ‐ and δ‐lactams in mostly good to excellent yields with broad substrate scope. We report a NaBArF4‐catalyzed oxidative cyclization of 1,5‐ and 1,6‐diynes via a presumable Lewis acid‐catalyzed SN2' pathway. This method leads to the efficient and practical construction of a diverse range of synthetically useful γ‐ and δ‐lactams in mostly good to excellent yields with broad substrate scope. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RING formation (Chemistry)
*LACTAMS
*OXIDATION
*CATALYSIS
*TRANSITION metals
Subjects
Details
- Language :
- English
- ISSN :
- 1001604X
- Volume :
- 37
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Chinese Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 133557876
- Full Text :
- https://doi.org/10.1002/cjoc.201800437