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Cisplatin and Ce6 loaded polyaniline nanoparticles: An efficient near-infrared light mediated synergistic therapeutic agent.
- Source :
-
Materials Science & Engineering: C . Feb2019, Vol. 95, p183-191. 9p. - Publication Year :
- 2019
-
Abstract
- Abstract Lipid-polymer hybrid nanoparticle was suggested to be a new and promising drug delivery agent due to the suitable particle size and controllable release. However, the low drug loading capacity has been a critical problem in the improvement of the nano-carrier systems. At present work, we have designed and developed smart nanoparticles with cholesterol-cisplatin (IV) conjugate contained to enhance the drug loading capacity. The predesigned drug delivery system showed enhanced synergistic effect through co-delivery of cisplatin and Ce6 and the drug released in a controllable way due to the polyaniline mediated photothermal conversion. The prepared polyaniline nanoparticles showed a favorable particle size of 109.6 nm and spread harmoniously in aqueous solution. Moreover, the near infrared radiation (NIR) stimulus-responsive characteristic of the polyaniline nanoparticles prompts the release of cisplatin from the nanoparticles inside the cytoplasm and the αvβ3/αvβ5 integrins targeted ligands (cRGD) enhanced the cellular uptake of the polyaniline nanoparticles in receptor-overexpressing MCF-7 cells. Furthermore, the singlet oxygen generated by Ce6 further enhances the cytotoxicity and obtained the expected synergistic effect with cisplatin. Thus, the prepared cRGD-conjugated co-delivery of cisplatin and Ce6 polyaniline nanoparticles consider to be a promising nanoplatform in nano-biomedicine. Highlights • Cisplatin coupled with cholesterol derivative and PEG-PCL, lecithin blend to produce nanoparticles were sustainable. • The prepared nanoparticles co-deliver two drugs of cisplatin and Ce6 for the purpose of synergistic therapy. • The polyaniline possess the capability to convert near infrared into heat for controlled release. • A cyclic Arg-Gly-Asp (cRGD) peptide ligand was employed for targeted delivey. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09284931
- Volume :
- 95
- Database :
- Academic Search Index
- Journal :
- Materials Science & Engineering: C
- Publication Type :
- Academic Journal
- Accession number :
- 133599490
- Full Text :
- https://doi.org/10.1016/j.msec.2018.03.031