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Prenylated flavans from Daphne giraldii and their cytotoxic activities.
- Source :
-
Fitoterapia . Jan2019, Vol. 132, p68-74. 7p. - Publication Year :
- 2019
-
Abstract
- Abstract Nine new prenylated flavan compounds with multi-chiral centers including two pairs of epimers were isolated from the stem and root bark of Daphne giraldii. Their structures were established by extensive NMR and HR-ESIMS spectroscopic data analyses. The in vitro cytotoxicity experiments indicated that compound 6 showed the most significant cytotoxicity against Hep3B cells, with an IC 50 value of 9.83 μ M. Hoechst 33258 and Annexin V-FITC/PI staining suggested that 6 could induce apoptosis of Hep3B cells in a concentration-dependent manner. Further mechanism study indicated that the apoptosis was associated with the up-regulations of Bax, cl-PARP and a decrease in Bcl-2 expression. Graphical abstract Unlabelled Image [ABSTRACT FROM AUTHOR]
- Subjects :
- *APOPTOSIS
*BARK
*CELL lines
*CHALONES
*CHROMATOGRAPHIC analysis
*FLAVONOIDS
*MEDICINAL plants
*MOLECULAR structure
*NUCLEAR magnetic resonance spectroscopy
*RESEARCH funding
*STATISTICS
*PLANT stems
*T-test (Statistics)
*PHYTOCHEMICALS
*PLANT extracts
*DATA analysis
*CELL survival
*CYTOTOXINS
*DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 132
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 133600539
- Full Text :
- https://doi.org/10.1016/j.fitote.2018.11.011